John E Wilkinson Selected Research

Pyruvate Kinase

3/2022	ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth.
1/2022	Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.

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John E Wilkinson Research Topics

Disease

23	Neoplasms (Cancer) 03/2022 - 11/2011
6	Neoplasm Metastasis (Metastasis) 01/2022 - 03/2014
4	Prostatic Neoplasms (Prostate Cancer) 01/2019 - 03/2014
4	Inflammation (Inflammations) 01/2018 - 09/2014
3	Carcinogenesis 03/2022 - 12/2017
3	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2018
3	Carcinoma (Carcinomatosis) 01/2022 - 11/2011
3	Hyperplasia 02/2014 - 11/2009
2	Adenocarcinoma 01/2022 - 01/2020
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 01/2021
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018 - 06/2014
2	Genetic Translocation (Chromosomal Translocation) 11/2011 - 11/2009
2	Follicular Adenocarcinoma 11/2011 - 11/2009
2	Infections 09/2005 - 06/2004
1	Hepatocellular Carcinoma (Hepatoma) 03/2022
1	Liver Neoplasms (Liver Cancer) 03/2022
1	Glioblastoma (Glioblastoma Multiforme) 03/2022
1	Triple Negative Breast Neoplasms 01/2022
1	Bites and Stings (Sting) 01/2022
1	Ovarian Neoplasms (Ovarian Cancer) 01/2022
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2021
1	Pancreatitis 01/2021
1	Lipidoses 11/2020
1	Type 2 Diabetes Mellitus (MODY) 11/2020
1	Cardiovascular Diseases (Cardiovascular Disease) 11/2020
1	Retinoblastoma (Glioblastoma, Retinal) 01/2020
1	Fibrolamellar hepatocellular carcinoma 12/2017
1	Fibrosis (Cirrhosis) 12/2017
1	Urinary Bladder Neoplasms (Bladder Cancer) 12/2015
1	Delayed Graft Function 07/2015
1	Muscular Dystrophies (Muscular Dystrophy) 01/2015
1	Pneumonia (Pneumonitis) 10/2014
1	Cataract (Cataracts) 08/2012
1	Thyroid Neoplasms (Thyroid Cancer) 11/2011

Drug/Important Bio-Agent (IBA)

7	Proteins (Proteins, Gene)FDA Link 12/2021 - 11/2009
4	Pharmaceutical PreparationsIBA 01/2022 - 01/2020
4	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2019 - 11/2009
3	Transcription Factors (Transcription Factor)IBA 12/2021 - 01/2013
3	CytokinesIBA 01/2021 - 10/2014
2	Protein Isoforms (Isoforms)IBA 03/2022 - 02/2014
2	Pyruvate KinaseIBA 03/2022 - 01/2022
2	Small Interfering RNA (siRNA)IBA 01/2022 - 01/2016
2	ChromatinIBA 01/2021 - 09/2014
2	AsparagineIBA 01/2018 - 01/2018
2	TensinsIBA 01/2017 - 11/2009
2	Biomarkers (Surrogate Marker)IBA 12/2015 - 06/2015
1	DNA (Deoxyribonucleic Acid)IBA 03/2022
1	Antisense OligonucleotidesIBA 03/2022
1	NexusIBA 01/2022
1	Immune Checkpoint InhibitorsIBA 01/2022
1	Doxycycline (Periostat)FDA LinkGeneric 01/2022
1	Methionine (L-Methionine)FDA Link 01/2022
1	Phenobarbital (Luminal)FDA Link 01/2022
1	PlatinumIBA 01/2022
1	Methionine Sulfoxide ReductasesIBA 01/2022
1	Hormones (Hormone)IBA 12/2021
1	Interleukin-33IBA 01/2021
1	AlarminsIBA 01/2021
1	LysophospholipidsIBA 11/2020
1	LipidsIBA 11/2020
1	Triglycerides (Triacylglycerol)IBA 11/2020
1	Acarbose FDA LinkGeneric 11/2020
1	Amino Acids FDA Link 11/2020
1	Codon (Codons)IBA 11/2020
1	Gemcitabine FDA Link 01/2020
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2020
1	Retinoblastoma ProteinIBA 01/2020
1	Aspartate-Ammonia Ligase (Asparagine Synthetase)IBA 01/2018
1	AP20187IBA 01/2018
1	Transcription Factor TFIID (TFIID)IBA 01/2018
1	LigandsIBA 01/2018
1	Asparaginase (Elspar)FDA Link 01/2018
1	3,5- diethoxycarbonyl- 1,4- dihydrocollidineIBA 12/2017
1	CateninsIBA 12/2017
1	Phosphotransferases (Kinase)IBA 12/2017
1	Complementary DNA (cDNA)IBA 12/2017
1	LGK974IBA 11/2017
1	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 01/2017
1	Oncogene Proteins (Oncogene Protein)IBA 01/2016
1	MicroRNAs (MicroRNA)IBA 12/2015
1	CreatinineIBA 07/2015
1	Interleukin-6 (Interleukin 6)IBA 06/2015
1	UtrophinIBA 01/2015
1	Poloxamer (Poloxamer 407)IBA 01/2015
1	Clodronic Acid (Clodronate)IBA 10/2014
1	DEAD-box RNA HelicasesIBA 06/2014
1	Extracellular Matrix ProteinsIBA 02/2014
1	RNA Splicing FactorsIBA 02/2014
1	TenascinIBA 02/2014
1	RNA Precursors (Precursor, mRNA)IBA 02/2014
1	Sirolimus (Rapamycin)FDA Link 08/2012
1	Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA 02/2012
1	Pioglitazone (Actos)FDA Link 11/2011
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 11/2011

Therapy/Procedure

12	Therapeutics 03/2022 - 03/2014
3	Drug Therapy (Chemotherapy) 01/2022 - 06/2014
2	Immunotherapy 01/2022 - 01/2020
2	Castration 01/2020 - 03/2014
1	Precision Medicine 01/2022
1	Prostatectomy (Retropubic Prostatectomy) 01/2017